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　　原标题：2017过敏性疾病机理研究新进展
　　本文综述了过敏性疾病的发病机制，特别是2型先天淋巴样细胞、TH2淋巴细胞、B细胞、树突状细胞、人体微生物组和屏障功能、嗜酸性粒细胞和肥大细胞方面的机理。在过去的一年里，在适应性(TH2)和2型先天淋巴样效应细胞控制的2型炎症的特征方面取得了相当大的进展。淋巴细胞活化、转运、募集和效应细胞机制的新途径已经被发现。淋巴细胞效应细胞应答的可塑性是另一个取得重大进展的领域。越来越多的证据将影响我们对过敏性疾病的理解以及我们预防和治疗过敏的努力。
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JACI
Advances in mechanisms of allergic disease in 2017
DOI: 10.1016/j.jaci.2018.09.027
Abstract:
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells, TH2 lymphocytes, B cells, dendritic cells, microbiome and barrier function, eosinophils, and mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (TH2) and type 2 innate lymphoid effector cells. New pathways of lymphocyte activation, trafficking, and recruitment and effector cell mechanisms have been discovered. The plasticity of lymphocyte effector cell responses is another area in which major progress has been achieved. Accumulating evidence will influence both our understanding of allergic disease and our efforts for allergy prevention and treatment.
All Authors:
ChrysanthiSkevakiMD, PhDabHaraldRenzMDa
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。