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　　原标题：欧洲榛子过敏的体外组份诊断
　　①对榛子的食物过敏同时伴或不伴花粉过敏。②我们试图在西班牙、瑞士和丹麦三个国家中评估一组榛子过敏原，用于榛子过敏的诊断。③52例对榛子双盲、安慰剂对照食物挑战试验结果呈阳性的患者;5例有过敏反应史;花粉过敏但榛子耐受62例;63例非特应性受试者作为对照。采用ImmunoCAP法对榛子提取物、重组榛子过敏原(rCor a 1.04、rCor a 2、rCor a 8、rCor a 11)、天然过敏原(nCor a 9、nCor a Bd8K、nCor a Bd11K)的血清特异性IgE水平进行分析。④榛子过敏患者中,91%(瑞士/西班牙，100%;丹麦，75%)有对榛子提取物，75%对rCor a1.04, 42%对rCor a2, 28%对rCor a8, 2%对rCor a11的特异性IgE。对Cor a 1.04的致敏率最高的是北部地区(瑞士/丹麦，100%;西班牙，18%)，而对脂质转移蛋白rCor a8的IgE在西班牙占优势(西班牙，71%;瑞士,15%;丹麦,5%)。对抑制蛋白 rCor a2的IgE分布均匀(40% ~ 45%)。在花粉过敏的对照组中，61%的人有对榛子提取物, 69%的人对rCor a 1.04, 34%的人对rCor a 2, 10%的人对rCor a 8, 6%的人对rCor a 11的特异性IgE。
　　⑤组份诊断分析显示，欧洲榛子过敏和榛子耐受患者的IgE谱存在显著差异。


延伸阅读
JACI:
Component-resolved in vitro diagnosis of hazelnut allergy in Europe
DOI: https://doi.org/10.1016/j.jaci.2009.02.005
Abstract:
Background
Background
Food allergy to hazelnut occurs both with and without concomitant pollen allergy.
Objective
We sought to evaluate a panel of hazelnut allergens for diagnosis of hazelnut allergy in Spain, Switzerland, and Denmark.
Methods
Fifty-two patients with a positive double-blind, placebo-controlled food challenge result with hazelnuts; 5 patients with a history of anaphylaxis; 62 patients with pollen allergy but hazelnut tolerance; and 63 nonatopic control subjects were included. Serum IgE levels to hazelnut extract, recombinant hazelnut allergens (rCor a 1.04, rCor a 2, rCor a 8, rCor a 11), and native allergens (nCor a 9, nCor a Bd8K, nCor a Bd11K) were analyzed by means of ImmunoCAP.
Results
Among patients with hazelnut allergy, 91% (Switzerland/Spain, 100%; Denmark, 75%) had IgE to hazelnut extract, 75% to rCor a 1.04, 42% to rCor a 2, 28% to rCor a 8, and 2% to rCor a 11. The highest rate of sensitization to Cor a 1.04 was found in the northern regions (Switzerland/Denmark, 100%; Spain, 18%), whereas IgE to the lipid transfer protein rCor a 8 prevailed in Spain (Spain, 71%; Switzerland, 15%; Denmark, 5%). IgE to profilin rCor a 2 was equally distributed (40% to 45%). Among control subjects with pollen allergy, 61% had IgE to hazelnut extract, 69% to rCor a 1.04, 34% to rCor a 2, 10% to rCor a 8, and 6% to rCor a 11.
Conclusion
Component-resolved in vitro analyses revealed substantial differences in IgE profiles of hazelnut allergic and hazelnut tolerant patients across Europe.
All Author:
Kirsten Skamstrup Hansen, MD, PhD'Correspondence information about the author MD, PhD Kirsten Skamstrup Hansen Email the author MD, PhD Kirsten Skamstrup Hansen, Barbara K. Ballmer-Weber, MD, PhD, Joaquin Sastre, MD, PhD, Jonas Lidholm PhD, Kerstin Andersson, PhD, Hubert Oberhofer, MD, Magdalena Lluch-Bernal, MD, Jonas Östling, PhD, Lars Mattsson, PhD,Frauke Schocker, hD, Stefan Viet, PhD, Lars K. Poulsen, PhDPlumX Metric
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。