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　　原标题：世界卫生组织/国际免疫学联合会过敏原命名法：提供一种通用的术语
　　过敏原的系统命名起源于20世纪80年代早期，当时只有很少蛋白质过敏原被描述。David G. Marsh博士领导的科学家团队基于Linnaean分类法发明了一种命名法，并在1986年进一步建立了世界卫生组织/国际免疫学会联盟(WHO/IUIS)过敏原命名小组委员会。它的目的是标准化抗原(过敏原)的名称，这些抗原(过敏原)在人类中引起IgE介导的过敏。小组委员会于一九八六年首次发表修订后的过敏原名单，直至一九九四年，该名单的数量不断增加。从1994年到2007年，该数据库是一个在线文本表格，随后转变为一个更容易更新的网站。过敏原列表成为过敏原命名数据库(www.allergen.org)，目前包含了大约880种不同来源的蛋白质。小组委员会包括临床和分子变态反应学专家。他们使用小组委员会制定的以证据为基础的标准来审查提交的过敏原候选蛋白。审查过程评估提交的过敏原生化分析报告和证据，目的是在发布前确定过敏原名称。该小组委员会负责维护和修订数据库，并应对不断出现的挑战，因为新的“组学”技术提供了越来越多关于潜在新过敏原的数据。大多数期刊发表新过敏原信息都需要一个正式的过敏原名称，包括向世卫组织/IUIS过敏原命名小组委员会提交机密数据，来证明过敏样本血清与纯化蛋白的结合。


延伸阅读
Molecular Immunology
WHO/IUIS Allergen Nomenclature: Providing a common language
https://doi.org/10.1016/j.molimm.2018.03.003
Abstract:
A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a text table online, then converted to a more readily updated website. The allergen list became the Allergen Nomenclature database (www.allergen.org), which currently includes approximately 880 proteins from a wide variety of sources. The Sub-Committee includes experts on clinical and molecular allergology. They review submissions of allergen candidates, using evidence-based criteria developed by the Sub-Committee. The review process assesses the biochemical analysis and the proof of allergenicity submitted, and aims to assign allergen names prior to publication. The Sub-Committee maintains and revises the database, and addresses continuous challenges as new “omics” technologies provide increasing data about potential new allergens. Most journals publishing information on new allergens require an official allergen name, which involves submission of confidential data to the WHO/IUIS Allergen Nomenclature Sub-Committee, sufficient to demonstrate binding of IgE from allergic subjects to the purified protein.
First Author:
Correspondence:
All Authors:
AnnaPomésaJanetM.DaviesbChristianeHilgerdThomasHolzhausereJonasLidholmfAndreas L.LopatagGeoffreyA.MuellerhAndreasNandyiChristianRadauerjSannyK.ChankUtaJappelJörgKleine-TebbemWayneR.ThomasnMartinD.ChapmanaMariannevanHageoRonaldvanReepStefanViethsq…Richard E.Goodmans
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。