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　　原标题：猫毛组分敏感与青年哮喘2型生物标志物有关联
　　① 猫毛敏感的分子模式因人而异，它们与哮喘患者炎症的关系还没有得到广泛的研究；② 纳入哮喘病人266人（10-35岁），其IgE对猫毛、狗毛和马毛敏感（ImmunoCAP），分析IgE对猫毛过敏原成分Fel d1(分泌球蛋白)、Fel d2(血清白蛋白)、Fel d4、Fel d7(脂蛋白)的影响；③ IgE对Fel d2的水平与FeNO (p=0.012)和总IgE (p<0.001)有相关；④IgE对于Fel d 1和猫毛提取的炎症标记物无任何关联(p = 0.23−0.51)；⑤ 青年哮喘患者血清中IgE对脂蛋白(Fel d 4)和血清白蛋白(Fel d 2)的水平与2型生物标志物和总IgE含量相关。


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Clinical & Experimental Allergy
Sensitisation to minor cat allergen components is associated with type-2 biomarkers in young asthmatics
DOI: 10.1111/cea.13135
Abstract:
Background: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisationvary between individuals, but their relationship to inflammation in asthmatics has not beenextensively studied.
Methods: Patients with asthma (age 10−35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins). Independent associations between IgE-antibody concentrations, and fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, and total IgE were analysed by multiple linear regression after adjustment for possible confounders.
Results: The level of IgE against Fel d 2 was independently related to FeNO (p=0.012) and total IgE (p<0.001), and IgE against Fel d 4 associated with Β-Eos count (p=0.009) and total IgE (p<0.001). IgE antibodies against Fel d 1 or cat extract did not independently relate to these inflammatory markers (p=0.23−0.51).
Conclusions: Levels of IgE to lipocalin (Fel d 4) and serum albumin (Fel d 2), but not to secretoglobin (Fel d 1) or cat extract, were independently associated with type-2 biomarkers and total IgE in young asthmatics.
First Author:
Tsolakis N.
Correspondence:
Department of Women’s and Children’s Health, Uppsala University
All Authors:
Tsolakis N, Malinovschi A, Nordvall L, Mattsson L, Lidholm J, Pedroletti C, Janson C, Borres M.P, and Alving K
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